杜仲叶中绿原酸的提取条件优化及其提取物的降血脂作用

doi:10.11707/j.1001-7488.20090127

林业科学 ›› 2009, Vol. 12 ›› Issue (1): 158-160.doi: 10.11707/j.1001-7488.20090127

杜仲叶中绿原酸的提取条件优化及其提取物的降血脂作用

左航^1,2　黄文^2,3　李天宏²　龚国华³　魏蒙³

(1．北京大学深圳研究生院城市人居环境科学与技术重点实验室　深圳 518055；2．北京大学环境工程系水沙科学教育部重点实验室　北京 100871；3．四川大学纳米生物医学技术与膜生物学研究所　四川大学华西医院肿瘤生物治疗国家重点实验室　成都 610041)

收稿日期:2007-12-03 修回日期:1900-01-01 出版日期:2009-01-25 发布日期:2009-01-25

Optimization of Extracting Chlorogenic Acid from Eucommia ulmoides Leaf and the Effect of the Extract on Hyperlipemia in Mice

Mice Zuo Hang^1,2,Huang Wen^2,3,Li Tianhong²,Gong Guohua³,WeiMeng³

(1. Shenzhen Graduate School of Peking University Key Laboratory for Environmental and Urban Sciences Shenzhen 518055; 2. Environmental Engineering Department of Peking University Key Laboratory for Water andSediment Sciences of Ministry of Education Beijing 100871; 3. Institute for Nanoblomedical Technology and Membrane Biology, Sichuan UniversIty State Key Laboratory of Biotherapy, West China Hospital，Sichuan University Chengdu 610041）

Received:2007-12-03 Revised:1900-01-01 Online:2009-01-25 Published:2009-01-25

摘要/Abstract

关键词: 关键词：杜仲叶, 绿原酸, 工艺优化, 调节血脂

Abstract:

Abstract: A protocol for extracting chlorogenic acid from Eucommia ulmoides leaf was optimized by orthogonal test on the base of noticeable factors test. The preventing effect of extract of Eucommia ulmoides leaf on mice suffered from high lipid serum was evaluated. High lipid serum was induced by gavaging fat emulsion to mice everyday. The TC,TG,LDL-C and HDL-C level in the serum of different animal groups were monitored. The result showed that the optimum process was to extract the chlorogenicacid at 90 ℃ with 70% ethanol for 2 h, with solid-liquid ratio 1∶16,and the extract rate was able to reach to 4%. The extract was efficient in defending high lipid serum.

Key words: Key words: Eucommia ulmoides leaf, chlorogenic acid, optimize process, accommodate hyperlipemiaient transfer rate

左航;黄文;李天宏　龚国华　魏蒙. 杜仲叶中绿原酸的提取条件优化及其提取物的降血脂作用[J]. 林业科学, 2009, 12(1): 158-160.

Mice Zuo Hang;Huang Wen;Li Tianhong;Gong Guohua;WeiMeng. Optimization of Extracting Chlorogenic Acid from Eucommia ulmoides Leaf and the Effect of the Extract on Hyperlipemia in Mice[J]. Scientia Silvae Sinicae, 2009, 12(1): 158-160.

[1]	董娟娥杜红岩张康健赵辉李周岐邵战波彭少兵. 观赏与药用杜仲无性系的选择*[J]. 林业科学, 2008, 44(5): 165-169.
[2]	张齐生孙丰文王建和. 竹材碎料复合板的结构和工艺的研究[J]. , 1995, 31(6): 536-542.

杜仲叶中绿原酸的提取条件优化及其提取物的降血脂作用

Optimization of Extracting Chlorogenic Acid from Eucommia ulmoides Leaf and the Effect of the Extract on Hyperlipemia in Mice

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