Abstract: [Objective] This study was carried out with aims to prepare a novel nano drug delivery system consisting of bamboo charcoal and Eucommia ulmoides, and to investigate its anticancer effects in vitro.[Method] The adsorption capacity of the nano-bamboo charcoal on Eucommia ulmoides extract was measured by Langmuir model, and the release experiment was carried out under intestinal fluid condition. Characteristic changes for the nano-bamboo charcoal drug delivery system with and without adsorption of Eucommia ulmoides were evaluated by scanning electron microscopy,Fourier transform infrared spectroscopy,thermogravimetric analysis,and specific surface area. In addition,the anticancer effect from this novel bamboo charcoal Eucommia ulmoides delivery system was evaluated against a human colon cancer cell line(HCT116).[Result] Nano-bamboo charcoal exhibited good adsorption capacity of the Eucommia ulmoides extract(up to 492.61 mg·g^-1 at 37℃. The cumulative release rate for the Eucommia ulmoides extract from this nano-bamboo charcoal delivery system was 70.67% and specific surface area of the nano-bamboo charcoal decreased from 820.32 m·g^-1 to 443.80 m²·g^-1 after the Eucommia ulmoides extract was loaded. Vitro anticancer study showed that the inhibition rate for the Eucommia ulmoides against HCT116 cancer cells was 23.07%,in this novel bamboo charcoal nano drug delivery system.[Conclusion] A novel strategy for the delivery of traditional Chinese medicine Eucommia ulmoides extract via bamboo charcoal nano drug delivery system was provided.

Key words: nano-bamboo charcoal(NBC), Eucommia ulmoides extract(EUE), adsorption, sustained release